The 646th episode of Saturday Night Live was hosted by John Malkovich. The musical guest was rapper T.I., who was accompanied in the second musical selection by Swizz Beatz.

Jamie-Lynn Sigler, Molly Sims, and Justin Timberlake made cameo appearances in one of this episode's Digital Shorts, entitled "Jizz in My Pants".

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Preceded by November 22, 2008 Tim McGraw/ Ludacris, T-Pain

Succeded by December 13, 2008 Hugh Laurie/ Kanye West

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